Clinical Disorders

Chair: Katholieke Universiteit Leuven

This cluster brings together clinical expertise across RADAR-CNS (Remote Assessment of Disease and Relapse – Central Nervous System) relating to our three focus conditions: depression, epilepsy and multiple sclerosis (MS).  This cluster focuses on evaluating the feasibility, adherence and personal satisfaction with remote measurement technologies in people with different conditions.  It also addresses the clinical harmonisation required to assess sleep, physical activity, speech, mood, and cognition in everyday life across clinical disorders.

Major Depressive Disorder (Work Package 6)

At the heart of this work package is a multicentre observational cohort study (RADAR-MDD) following patients with recurrent depressive disorder.  Participants will use remote measurement technologies whilst being followed for clinical outcomes (particularly, though not exclusively, recurrence and relapse) over the course of 12 months. This study will be complemented by learning from the ORBIT study (Janssen) and, although not identical in design, the two studies will be sufficiently close to allow us to test whether findings from one generalise to the other.  The project lead of the Orbit study is a participant of this work package and will provide the full support and experience required.

Epilepsy (Work Package 4)

We are initiating a set of studies into remote measurement technologies across a range of parameters.  We aim to determine the feasibility, acceptability of, and adherence to, remote measurement technologies in people with epilepsy to provide real-time objective, multidimensional indications of seizure occurrence and clinical state in epilepsy.  We are also exploring whether the trajectory of non-seizure-related aspects (eg. stress, mood) associate with, and predict/anticipate, changes in the trajectory of frequency of seizure occurrence.

Multiple Sclerosis (Work Package 5)

Exploring whether remote measurement technologies can be used to characterise two important features of clinical presentation, depression and gait disturbance in people with multiple sclerosis (MS).  We are determining whether remote measurement technologies can detect mood changes in MS patients in the early stages of their condition, and exploring whether they can reliably assess the clinical disability of MS patients.  We are also investigating these technologies’ sensitivity in detecting state changes and disability progression over time, evaluating the interaction among fatigue, depression and sleep disorder and sensory-motor dysfunction, including gait.

Clinical Harmonisation (Work Package 3)

Providing an overarching assessment and analysis scheme to assess sleep, physical activity, speech, mood, and cognition in everyday life across clinical disorders. We are focusing on variability in sleep quality, levels of activity, social interactions, mood, cognitive performance and stress as possible predictors of clinical course.  We are also examining how remote measurement technologies can monitor and improve quality of life and psychological well-being for people with depression, epilepsy, or multiple sclerosis.